Pub. Date : 2020
PMID : 33927788
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Epidemiological studies have shown that nicotine consumption decreases PD prevalence through neuroprotective mechanisms activation associated with the overstimulation of signaling pathways (SP) such as PI3K/AKT through nicotinic acetylcholine receptors (e.g alpha7 nAChRs) and over-expression of anti-apoptotic genes such as Bcl-2. | Nicotine | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Methods: We present a computational strategy integrating structural bioinformatics, SP manual reconstruction, and deep learning to predict the potential neuroprotective activity of 8 novel nicotine analogs over the behavior of PI3K/AKT. | Nicotine | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Results: Our model was able to predict the potential neuroprotective activity of seven new nicotine analogs based on the binomial Bcl-2 response regulated by the activation of PI3K/AKT. | Nicotine | AKT serine/threonine kinase 1 | Homo sapiens |