Title : Heme Oxygenase-1 Signaling and Redox Homeostasis in Physiopathological Conditions.

Pub. Date : 2021 Apr 16

PMID : 33923744






1 Functional Relationships(s)
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1 The contribution of HO-1 in redox homeostasis leads to a relevant decrease in cells oxidative damage, which can be reconducted to its cytoprotective effects explicated alongside other endogenous mechanisms involving genes like TIGAR (TP53-induced glycolysis and apoptosis regulator), but also to the therapeutic functions of heme main transformation products, especially carbon monoxide (CO), which has been shown to be effective on GSH levels implementation sustaining body"s antioxidant response to oxidative stress. Heme heme oxygenase 1 Homo sapiens