Pub. Date : 2021 Apr 15
PMID : 33920802
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Moreover, enhanced ROS generation by Rh1 inhibited the activation of the PI3K/Akt pathway. | 2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Consistently, Rh1 treatment significantly reduced tumor growth in vivo and increased the ROS production and protein expression of LC3B and cleaved caspase-3 but decreased the phosphorylation of Akt and retinoblastoma (Rb) in tumor tissues. | 2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Taken together, Rh1 exerted a potential anticancer effect on BC cells by inducing cell cycle arrest, apoptosis, and autophagy via inhibition of the ROS-mediated PI3K/Akt pathway. | 2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone | AKT serine/threonine kinase 1 | Homo sapiens |