Pub. Date : 2021 Apr 27
PMID : 33910001
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Leucine-sensing mechanism of leucyl-tRNA synthetase 1 for mTORC1 activation. | Leucine | CREB regulated transcription coactivator 1 | Mus musculus |
| 2 | Leucyl-tRNA synthetase 1 (LARS1) mediates activation of leucine-dependent mechanistic target of rapamycin complex 1 (mTORC1) as well as ligation of leucine to its cognate tRNAs, yet its mechanism of leucine sensing is poorly understood. | Leucine | CREB regulated transcription coactivator 1 | Mus musculus |
| 3 | We determine different crystal structures of LARS1 complexed with leucine, ATP, and a reaction intermediate analog, leucyl-sulfamoyl-adenylate (Leu-AMS), and find two distinct functional states of LARS1 for mTORC1 activation. | Leucine | CREB regulated transcription coactivator 1 | Mus musculus |
| 4 | Thus, this work unveils the structural basis for leucine-dependent long-range communication between the catalytic and RagD-binding domains of LARS1 for mTORC1 activation. | Leucine | CREB regulated transcription coactivator 1 | Mus musculus |