Title : Interleukin-6 participates in human pancreatic stellate cell activation and collagen I production via TGF-β1/Smad pathway.

Pub. Date : 2021 Jul

PMID : 33893003






5 Functional Relationships(s)
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1 In in vitro studies, we identified that IL-6R expression or IL-6 and TGF-beta1 secretions were significantly increased in, respectively, Mphis and PSCs by ethanol (EtOH) or lipopolysaccharide (LPS) stimulation while EtOH- or LPS-induced alpha-SMA or Col1a1 mRNA and protein production in PSCs were partially blocked by IL-6 antibody. Ethanol interleukin 6 Homo sapiens
2 In in vitro studies, we identified that IL-6R expression or IL-6 and TGF-beta1 secretions were significantly increased in, respectively, Mphis and PSCs by ethanol (EtOH) or lipopolysaccharide (LPS) stimulation while EtOH- or LPS-induced alpha-SMA or Col1a1 mRNA and protein production in PSCs were partially blocked by IL-6 antibody. Ethanol interleukin 6 Homo sapiens
3 In in vitro studies, we identified that IL-6R expression or IL-6 and TGF-beta1 secretions were significantly increased in, respectively, Mphis and PSCs by ethanol (EtOH) or lipopolysaccharide (LPS) stimulation while EtOH- or LPS-induced alpha-SMA or Col1a1 mRNA and protein production in PSCs were partially blocked by IL-6 antibody. Ethanol interleukin 6 Homo sapiens
4 In in vitro studies, we identified that IL-6R expression or IL-6 and TGF-beta1 secretions were significantly increased in, respectively, Mphis and PSCs by ethanol (EtOH) or lipopolysaccharide (LPS) stimulation while EtOH- or LPS-induced alpha-SMA or Col1a1 mRNA and protein production in PSCs were partially blocked by IL-6 antibody. Ethanol interleukin 6 Homo sapiens
5 In in vitro studies, we identified that IL-6R expression or IL-6 and TGF-beta1 secretions were significantly increased in, respectively, Mphis and PSCs by ethanol (EtOH) or lipopolysaccharide (LPS) stimulation while EtOH- or LPS-induced alpha-SMA or Col1a1 mRNA and protein production in PSCs were partially blocked by IL-6 antibody. Ethanol interleukin 6 Homo sapiens