Title : Double stranded RNA drives anti-viral innate immune responses, sickness behavior and cognitive dysfunction dependent on dsRNA length, IFNAR1 expression and age.

Pub. Date : 2021 Jul

PMID : 33892139






2 Functional Relationships(s)
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1 High molecular weight (HMW) poly I:C (1-6kb, 12 mg/kg) produced more robust sickness behavior and more robust IL-6, IFN-I and TNF-alpha responses than poly I:C of <500 bases (low MW) preparations. Poly I-C interleukin 6 Mus musculus
2 In aged animals, poly I:C induced exaggerated IL-6, IL-1beta and IFN-I in the plasma and similar exaggerated brain cytokine responses. Poly I-C interleukin 6 Mus musculus