Title : SCA7 Mouse Cerebellar Pathology Reveals Preferential Downregulation of Key Purkinje Cell-Identity Genes and Shared Disease Signature with SCA1 and SCA2.

Pub. Date : 2021 Jun 2

PMID : 33888607






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 SCA7 is caused by polyglutamine expansion in ATXN7, a subunit of the transcriptional coactivator SAGA, which harbors histone modification activities. polyglutamine ataxin 7 Mus musculus
2 SCA7 is caused by polyglutamine expansion in ATXN7, a subunit of the transcriptional coactivator SAGA, which harbors histone modification activities. polyglutamine ataxin 7 Mus musculus
3 SCA7140Q/5Q mice represent an accurate model for the investigation of different aspects of SCA7 pathogenesis.Significance statementSpinocerebellar ataxia 7 (SCA7) is one of the several forms of inherited SCAs characterized by cerebellar degeneration due to polyglutamine expansion in specific proteins. polyglutamine ataxin 7 Mus musculus
4 SCA7140Q/5Q mice represent an accurate model for the investigation of different aspects of SCA7 pathogenesis.Significance statementSpinocerebellar ataxia 7 (SCA7) is one of the several forms of inherited SCAs characterized by cerebellar degeneration due to polyglutamine expansion in specific proteins. polyglutamine ataxin 7 Mus musculus