Pub. Date : 2021
PMID : 33883905
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Calycosin Induces Gastric Cancer Cell Apoptosis via the ROS-Mediated MAPK/STAT3/NF-kappaB Pathway. | 7,3'-dihydroxy-4'-methoxyisoflavone | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | Calycosin also decreased the expression of extracellular signal-regulated kinase, nuclear factor kappa B (NF-kappaB), and signal transducer and activator of transcription 3 (STAT3), and increased the phosphorylation levels of p38, c-Jun N-terminal kinase, and inhibitor of NF-kappaB. | 7,3'-dihydroxy-4'-methoxyisoflavone | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | Calycosin also decreased the expression of extracellular signal-regulated kinase, nuclear factor kappa B (NF-kappaB), and signal transducer and activator of transcription 3 (STAT3), and increased the phosphorylation levels of p38, c-Jun N-terminal kinase, and inhibitor of NF-kappaB. | 7,3'-dihydroxy-4'-methoxyisoflavone | nuclear factor kappa B subunit 1 | Homo sapiens |
| 4 | Calycosin also decreased the expression of extracellular signal-regulated kinase, nuclear factor kappa B (NF-kappaB), and signal transducer and activator of transcription 3 (STAT3), and increased the phosphorylation levels of p38, c-Jun N-terminal kinase, and inhibitor of NF-kappaB. | 7,3'-dihydroxy-4'-methoxyisoflavone | nuclear factor kappa B subunit 1 | Homo sapiens |
| 5 | Conclusion: In summary, calycosin induces apoptosis via ROS-mediated MAPK/STAT3/NF-kappaB pathways, thereby exerting its anti-carcinogenic functions in GC cells. | 7,3'-dihydroxy-4'-methoxyisoflavone | nuclear factor kappa B subunit 1 | Homo sapiens |