Title : Amino acids and RagD potentiate mTORC1 activation in CD8+ T cells to confer antitumor immunity.

Pub. Date : 2021 Apr

PMID : 33883257






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Moreover, the limited T-cell access to leucine (LEU), overshadowed by tumor cell amino acid consumption, led to impaired RagD-dependent mTORC1 activity. Leucine CREB regulated transcription coactivator 1 Mus musculus
2 Moreover, the limited T-cell access to leucine (LEU), overshadowed by tumor cell amino acid consumption, led to impaired RagD-dependent mTORC1 activity. Leucine CREB regulated transcription coactivator 1 Mus musculus
3 The characterization the role of RagD and LEU in nutrient mTORC1 signaling in TILs might suggest potential therapeutic strategies based on the manipulation of RagD and its upstream pathway. Leucine CREB regulated transcription coactivator 1 Mus musculus