Title : ADAM17 Boosts Cholesterol Efflux and Downstream Effects of High-Density Lipoprotein on Inflammatory Pathways in Macrophages.

Pub. Date : 2021 Jun

PMID : 33882688






1 Functional Relationships(s)
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1 Sorted thioglycollate-elicited peritoneal macrophages freshly isolated from APOA1Tg; Ldlr-/- mice, which have higher HDL levels than Ldlr-/- controls, showed reduced expression of interferon-inducible genes in response to lipopolysaccharide or interferon-beta, but exacerbated proinflammatory responses to lipopolysaccharide for Tnfa, Cxcl1, Ccl2, and Il1b, phenocopying cells stimulated with HDL in vitro. Thioglycolates interleukin 1 beta Mus musculus