Title : WEE1 Inhibition in Combination With Targeted Agents and Standard Chemotherapy in Preclinical Models of Pancreatic Ductal Adenocarcinoma.

Pub. Date : 2021

PMID : 33869031






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 In PDX models with mutated p53 status, there was significant tumor growth inhibition from the combination of AZD1775 with irinotecan or capecitabine (P <= 0.03), while PDX models with wild type p53 did not show anti-tumor synergy from the same combinations (P >= 0.08). Irinotecan tumor protein p53 Homo sapiens