Title : β-elemene affects angiogenesis of infantile hemangioma by regulating angiotensin-converting enzyme 2 and hypoxia-inducible factor-1 alpha.

Pub. Date : 2021 Jun

PMID : 33861415






4 Functional Relationships(s)
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1 beta-elemene affects angiogenesis of infantile hemangioma by regulating angiotensin-converting enzyme 2 and hypoxia-inducible factor-1 alpha. beta-elemene hypoxia inducible factor 1 subunit alpha Homo sapiens
2 Moreover, if the concentration of beta-elemene reached 40 mug/ml or higher, the expression of HIF-1-alpha decreased. beta-elemene hypoxia inducible factor 1 subunit alpha Homo sapiens
3 Taken together, our data indicated that the different effects of beta-elemene on the proliferation, migration and angiogenesis of hemangioma at different concentrations: The ACE2 signaling pathway dominates with treatment of low concentrations of beta-elemene, stimulating the expression of downstream VEGFA to promote the angiogenesis of hemangioma; under the condition of high concentrations of beta-elemene, the HIF-1-alpha signaling pathway inhibits the expression of VEGFA and further inhibits the angiogenesis of hemangioma. beta-elemene hypoxia inducible factor 1 subunit alpha Homo sapiens
4 Taken together, our data indicated that the different effects of beta-elemene on the proliferation, migration and angiogenesis of hemangioma at different concentrations: The ACE2 signaling pathway dominates with treatment of low concentrations of beta-elemene, stimulating the expression of downstream VEGFA to promote the angiogenesis of hemangioma; under the condition of high concentrations of beta-elemene, the HIF-1-alpha signaling pathway inhibits the expression of VEGFA and further inhibits the angiogenesis of hemangioma. beta-elemene hypoxia inducible factor 1 subunit alpha Homo sapiens