Pub. Date : 2021 Jun
PMID : 33861415
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | beta-elemene affects angiogenesis of infantile hemangioma by regulating angiotensin-converting enzyme 2 and hypoxia-inducible factor-1 alpha. | beta-elemene | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
| 2 | Moreover, if the concentration of beta-elemene reached 40 mug/ml or higher, the expression of HIF-1-alpha decreased. | beta-elemene | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
| 3 | Taken together, our data indicated that the different effects of beta-elemene on the proliferation, migration and angiogenesis of hemangioma at different concentrations: The ACE2 signaling pathway dominates with treatment of low concentrations of beta-elemene, stimulating the expression of downstream VEGFA to promote the angiogenesis of hemangioma; under the condition of high concentrations of beta-elemene, the HIF-1-alpha signaling pathway inhibits the expression of VEGFA and further inhibits the angiogenesis of hemangioma. | beta-elemene | hypoxia inducible factor 1 subunit alpha | Homo sapiens |
| 4 | Taken together, our data indicated that the different effects of beta-elemene on the proliferation, migration and angiogenesis of hemangioma at different concentrations: The ACE2 signaling pathway dominates with treatment of low concentrations of beta-elemene, stimulating the expression of downstream VEGFA to promote the angiogenesis of hemangioma; under the condition of high concentrations of beta-elemene, the HIF-1-alpha signaling pathway inhibits the expression of VEGFA and further inhibits the angiogenesis of hemangioma. | beta-elemene | hypoxia inducible factor 1 subunit alpha | Homo sapiens |