Pub. Date : 2021 Jun
PMID : 33857568
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Increased DDIT3 in these Dox-treated cardiomyocytes at 24h suggested that increased MitoBax may have promoted ER stress related changes in DDIT3. | Doxorubicin | DNA damage inducible transcript 3 | Homo sapiens |
| 2 | Increased DDIT3 in these Dox-treated cardiomyocytes at 24h suggested that increased MitoBax may have promoted ER stress related changes in DDIT3. | Doxorubicin | DNA damage inducible transcript 3 | Homo sapiens |
| 3 | In contrast, breast cancer MCF7 cells showed an ER stress response to Dox with increased DDIT3 as early as 3h which may have triggered a positive feedback activation of ATF6 at 12 and 24h and promoted Calnexin. | Doxorubicin | DNA damage inducible transcript 3 | Homo sapiens |
| 4 | DDIT3 response in tumors was evoked by Dox, however this response was inversely correlated with increased Bip and Bax expression in hearts from tumor bearing animals. | Doxorubicin | DNA damage inducible transcript 3 | Homo sapiens |
| 5 | It is suggested that in Dox-induced cardiotoxicity both mitochondrial and ER stresses play an integral role through a mutual interaction where an inhibition of DDIT3 or Calnexin may also be crucial to achieve Dox resistance in cardiomyocytes. | Doxorubicin | DNA damage inducible transcript 3 | Homo sapiens |
| 6 | It is suggested that in Dox-induced cardiotoxicity both mitochondrial and ER stresses play an integral role through a mutual interaction where an inhibition of DDIT3 or Calnexin may also be crucial to achieve Dox resistance in cardiomyocytes. | Doxorubicin | DNA damage inducible transcript 3 | Homo sapiens |