Title : Selective inhibition of drug oxidation after simultaneous administration of two probe drugs, antipyrine and tolbutamide.

Pub. Date : 1988

PMID : 3383988






1 Functional Relationships(s)
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1 The two main inferences are first, that tolbutamide and antipyrine are metabolised by different forms of cytochrome P-450, and second that a battery of model substrates is needed to investigate the inhibitory effects of a drug in man. Tolbutamide cytochrome P450 family 4 subfamily F member 3 Homo sapiens