Pub. Date : 2021 Jun 25
PMID : 33838147
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here we present three cryo-EM structures of nanodisc-reconstituted, human ABCG2 bound to anticancer drugs tariquidar, topotecan and mitoxantrone. | tariquidar | ATP binding cassette subfamily G member 2 (Junior blood group) | Homo sapiens |
| 2 | We observed that the binding pocket of ABCG2 can accommodate a single tariquidar molecule in a C-shaped conformation, similar to one of the two tariquidar molecules bound to ABCB1, where tariquidar acts as an inhibitor. | tariquidar | ATP binding cassette subfamily G member 2 (Junior blood group) | Homo sapiens |
| 3 | We observed that the binding pocket of ABCG2 can accommodate a single tariquidar molecule in a C-shaped conformation, similar to one of the two tariquidar molecules bound to ABCB1, where tariquidar acts as an inhibitor. | tariquidar | ATP binding cassette subfamily G member 2 (Junior blood group) | Homo sapiens |
| 4 | We observed that the binding pocket of ABCG2 can accommodate a single tariquidar molecule in a C-shaped conformation, similar to one of the two tariquidar molecules bound to ABCB1, where tariquidar acts as an inhibitor. | tariquidar | ATP binding cassette subfamily G member 2 (Junior blood group) | Homo sapiens |