Pub. Date : 2021 Feb
PMID : 33832420
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Retinoic acid (RA) binding proteins, CRABP1 and CRABP2, are molecular chaperones that mediate intracellular activity of RA, the key promoter of cell differentiation with tumor suppressor activity. | Tretinoin | cellular retinoic acid binding protein 1 | Homo sapiens |
| 2 | Retinoic acid (RA) binding proteins, CRABP1 and CRABP2, are molecular chaperones that mediate intracellular activity of RA, the key promoter of cell differentiation with tumor suppressor activity. | Tretinoin | cellular retinoic acid binding protein 1 | Homo sapiens |
| 3 | The functions of CRABP1 are less studied but are apparently associated with sequestration of RA in cytoplasm and limitation of its transcriptional activity, suggesting involvement of this protein in the development of RA resistance. | Tretinoin | cellular retinoic acid binding protein 1 | Homo sapiens |
| 4 | Moreover, suppression of the CRABP1 level in both RA-sensitive and RA-resistant cells was shown in the cells with cells with knockdown of CRABP2 gene. | Tretinoin | cellular retinoic acid binding protein 1 | Homo sapiens |