Pub. Date : 2021 Jun
PMID : 33831397
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Homoharringtonine synergizes with quizartinib in FLT3-ITD acute myeloid leukemia by targeting FLT3-AKT-c-Myc pathway. | quizartinib | fms related receptor tyrosine kinase 3 | Homo sapiens |
| 2 | Mechanistically, HHT and quizartinib cooperatively inhibit FLT3-AKT and its downstream targets GSK3beta, c-Myc, and cyclin D1, cooperatively up-regulate the pro-apoptosis proteins Bim and Bax, and down-regulate the anti-apoptosis protein Mcl1. | quizartinib | fms related receptor tyrosine kinase 3 | Homo sapiens |