Title : Homoharringtonine synergizes with quizartinib in FLT3-ITD acute myeloid leukemia by targeting FLT3-AKT-c-Myc pathway.

Pub. Date : 2021 Jun

PMID : 33831397






1 Functional Relationships(s)
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1 Mechanistically, HHT and quizartinib cooperatively inhibit FLT3-AKT and its downstream targets GSK3beta, c-Myc, and cyclin D1, cooperatively up-regulate the pro-apoptosis proteins Bim and Bax, and down-regulate the anti-apoptosis protein Mcl1. quizartinib glycogen synthase kinase 3 alpha Homo sapiens