Title : Effects of memantine and its metabolite Mrz 2/373 on soman-induced inhibition of acetylcholinesterase in vitro.

Pub. Date : 2021 Jun 1

PMID : 33831382






4 Functional Relationships(s)
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1 Effects of memantine and its metabolite Mrz 2/373 on soman-induced inhibition of acetylcholinesterase in vitro. Soman acetylcholinesterase (Cartwright blood group) Homo sapiens
2 Addition of soman 7.5 nmol/l induced gradual AChE inhibition that became almost complete after 20 min. Soman acetylcholinesterase (Cartwright blood group) Homo sapiens
3 It was concluded that it is possible that memantine and Mrz 2/373 can prevent AChE from inhibition by soman, which could, along with known memantine"s neuroprotective activity, explain its potent antidotal effect in soman poisoning. Soman acetylcholinesterase (Cartwright blood group) Homo sapiens
4 The potential effect on aging of the soman-AChE complex warrants further studies. Soman acetylcholinesterase (Cartwright blood group) Homo sapiens