Title : PBPK modeling to predict drug-drug interactions of ivosidenib as a perpetrator in cancer patients and qualification of the Simcyp platform for CYP3A4 induction.

Pub. Date : 2021 Jun

PMID : 33822485






1 Functional Relationships(s)
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1 The in vivo CYP3A4 induction effect of ivosidenib was quantified using 4beta-hydroxycholesterol and was subsequently verified with the PK data from an ivosidenib and venetoclax combination study. cholest-5-ene-3,4-diol cytochrome P450 family 3 subfamily A member 4 Homo sapiens