Pub. Date : 2021 Apr 20
PMID : 33822049
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | SUMMARY ANSWER: Podocalyxin (PCX), a transmembrane protein, was identified as a key negative regulator of endometrial epithelial receptivity; specific downregulation of PCX in the luminal epithelium in the mid-secretory phase, likely mediated by progesterone, may act as a critical step in converting endometrial surface from a non-receptive to an implantation-permitting state. | Progesterone | podocalyxin like | Homo sapiens |
| 2 | SUMMARY ANSWER: Podocalyxin (PCX), a transmembrane protein, was identified as a key negative regulator of endometrial epithelial receptivity; specific downregulation of PCX in the luminal epithelium in the mid-secretory phase, likely mediated by progesterone, may act as a critical step in converting endometrial surface from a non-receptive to an implantation-permitting state. | Progesterone | podocalyxin like | Homo sapiens |
| 3 | SUMMARY ANSWER: Podocalyxin (PCX), a transmembrane protein, was identified as a key negative regulator of endometrial epithelial receptivity; specific downregulation of PCX in the luminal epithelium in the mid-secretory phase, likely mediated by progesterone, may act as a critical step in converting endometrial surface from a non-receptive to an implantation-permitting state. | Progesterone | podocalyxin like | Homo sapiens |
| 4 | To investigate whether PCX is regulated by progesterone, the master driver of endometrial differentiation, primary HEECs were treated in culture with estradiol and progesterone and analyzed by RT-PCR (n = 5) and western blot (n = 4). | Progesterone | podocalyxin like | Homo sapiens |
| 5 | Progesterone was confirmed to be able to suppress PCX in primary HEECs, suggesting this hormone likely mediates the downregulation of luminal PCX in vivo for receptivity. | Progesterone | podocalyxin like | Homo sapiens |
| 6 | Progesterone was confirmed to be able to suppress PCX in primary HEECs, suggesting this hormone likely mediates the downregulation of luminal PCX in vivo for receptivity. | Progesterone | podocalyxin like | Homo sapiens |
| 7 | Future study would need to investigate how progesterone differentially regulates PCX in endometrial epithelial subtypes. | Progesterone | podocalyxin like | Homo sapiens |
| 8 | The study also discovered PCX as progesterone target in HEECs, identifying a potentially useful functional biomarker to monitor progesterone action, such as in the optimization of progesterone type/dose/route of administration for luteal support. | Progesterone | podocalyxin like | Homo sapiens |
| 9 | The study also discovered PCX as progesterone target in HEECs, identifying a potentially useful functional biomarker to monitor progesterone action, such as in the optimization of progesterone type/dose/route of administration for luteal support. | Progesterone | podocalyxin like | Homo sapiens |
| 10 | The study also discovered PCX as progesterone target in HEECs, identifying a potentially useful functional biomarker to monitor progesterone action, such as in the optimization of progesterone type/dose/route of administration for luteal support. | Progesterone | podocalyxin like | Homo sapiens |