Pub. Date : 2021 Apr 5
PMID : 33821842
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Pretreatment HLADQA1-HLADRB1 Testing for the Prevention of Azathioprine-Induced Pancreatitis in Inflammatory Bowel Disease: A Prospective Cohort Study. | Azathioprine | major histocompatibility complex, class II, DQ alpha 1 | Homo sapiens |
| 2 | The haplotype HLADQA1-HLADRB1*07:01A>C is strongly associated with azathioprine-induced pancreatitis in IBD. | Azathioprine | major histocompatibility complex, class II, DQ alpha 1 | Homo sapiens |
| 3 | We aimed to evaluate whether pretreatment HLADQA1-HLADRB1*07:01A>C screening will reduce the risk of azathioprine-induced pancreatitis. | Azathioprine | major histocompatibility complex, class II, DQ alpha 1 | Homo sapiens |
| 4 | RESULTS: HLADQA1-HLADRB1*07:01A>C screening resulted in an 11-fold reduction in the incidence of azathioprine-induced pancreatitis (n = 1/328 or 0.30% vs n = 13/373 or 3.4%). | Azathioprine | major histocompatibility complex, class II, DQ alpha 1 | Homo sapiens |
| 5 | DISCUSSION: HLADQA1-HLADRB1*07:01A>C screening reduced the risk of azathioprine-induced pancreatitis; however, using this strategy to guide the use of azathioprine therapy in IBD may eliminate a large proportion of patients from being eligible for treatment with azathioprine. | Azathioprine | major histocompatibility complex, class II, DQ alpha 1 | Homo sapiens |
| 6 | DISCUSSION: HLADQA1-HLADRB1*07:01A>C screening reduced the risk of azathioprine-induced pancreatitis; however, using this strategy to guide the use of azathioprine therapy in IBD may eliminate a large proportion of patients from being eligible for treatment with azathioprine. | Azathioprine | major histocompatibility complex, class II, DQ alpha 1 | Homo sapiens |
| 7 | DISCUSSION: HLADQA1-HLADRB1*07:01A>C screening reduced the risk of azathioprine-induced pancreatitis; however, using this strategy to guide the use of azathioprine therapy in IBD may eliminate a large proportion of patients from being eligible for treatment with azathioprine. | Azathioprine | major histocompatibility complex, class II, DQ alpha 1 | Homo sapiens |
| 8 | In regions where there is access to other IBD therapies, and given the short-term and long-term toxicities associated with azathioprine, HLADQA1-HLADRB1*07:01A>C-screening may be a clinically relevant strategy for enhancing the safe use of azathioprine in IBD. | Azathioprine | major histocompatibility complex, class II, DQ alpha 1 | Homo sapiens |
| 9 | In regions where there is access to other IBD therapies, and given the short-term and long-term toxicities associated with azathioprine, HLADQA1-HLADRB1*07:01A>C-screening may be a clinically relevant strategy for enhancing the safe use of azathioprine in IBD. | Azathioprine | major histocompatibility complex, class II, DQ alpha 1 | Homo sapiens |