Pub. Date : 2021 Mar 23
PMID : 33806765
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Taken together, these findings indicated that the hypoxia-induced atrial profibrotic response occurs mainly via the ROS/JNK pathway, its downstream upregulation of HIF-1alpha and c-Jun/ATF2 phosphorylation and nuclear translocation to up-regulate the expression of fibrosis-related proteins (COL1A, COL3A, TGF-beta1 and alpha-SMA). | Reactive Oxygen Species | mitogen-activated protein kinase 8 | Homo sapiens |
| 2 | Our result suggests that suppression of ROS/JNK signaling pathway is a critical mechanism for developing a novel therapeutic strategy against atrial fibrillation. | Reactive Oxygen Species | mitogen-activated protein kinase 8 | Homo sapiens |