Title : Synthesis and Structure-Activity Relationships of Aristoyagonine Derivatives as Brd4 Bromodomain Inhibitors with X-ray Co-Crystal Research.

Pub. Date : 2021 Mar 17

PMID : 33802888






1 Functional Relationships(s)
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1 Co-crystal structures of these five inhibitors with human Brd4 bromodomain demonstrated that it has a key binding mode occupying the hydrophobic pocket, which is known to be the acetylated lysine binding site. Lysine bromodomain containing 4 Homo sapiens