Title : Assessment of 9-OH- and 7,8-diol-benzo[a]pyrene in Blood as Potent Markers of Cognitive Impairment Related to benzo[a]pyrene Exposure: An Animal Model Study.

Pub. Date : 2021 Mar 8

PMID : 33800341






2 Functional Relationships(s)
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Protein Name
Organism
1 Repeated oral administration of B[a]P led to, at the doses of 20 and 200 mg/kg/day, significant overexpression of Cyp1a1/Cyp1b1 in 2 out of the 3 brain regions considered, thereby suggesting the ability of the brain to metabolize B[a]P itself. Benzo(a)pyrene cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus
2 Repeated oral administration of B[a]P led to, at the doses of 20 and 200 mg/kg/day, significant overexpression of Cyp1a1/Cyp1b1 in 2 out of the 3 brain regions considered, thereby suggesting the ability of the brain to metabolize B[a]P itself. Benzo(a)pyrene cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus