Title : Calcium channel blockers lercanidipine and amlodipine inhibit YY1/ERK/TGF-β mediated transcription and sensitize the gastric cancer cells to doxorubicin.

Pub. Date : 2021 Aug

PMID : 33771646






2 Functional Relationships(s)
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Protein Name
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1 While doxorubicin was identified to activate the pathways TGF-beta and ERK/MAPK, lercanidipinewas found to inhibit these pathways. Doxorubicin mitogen-activated protein kinase 1 Homo sapiens
2 In multiple cellular models from different lineages, the cells with less sensitivity to doxorubicin were found to have the inherent activation of ERK/MAPK and TGF-beta pathways. Doxorubicin mitogen-activated protein kinase 1 Homo sapiens