Pub. Date : 2021 Jul
PMID : 33761308
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We show here that the levels of kindlin-2 and its binding partner PYCR1, a key enzyme for proline synthesis, are significantly increased in the lung tissues of human patients with pulmonary fibrosis. | Proline | pyrroline-5-carboxylate reductase 1 | Homo sapiens |
| 2 | Treatment of human lung fibroblasts with TGF-beta1 markedly increased the expression of kindlin-2 and PYCR1, resulting in increased kindlin-2 mitochondrial translocation, formation of the kindlin-2-PYCR1 complex and proline synthesis. | Proline | pyrroline-5-carboxylate reductase 1 | Homo sapiens |