Title : Bruton's agammaglobulinemia tyrosine kinase (Btk) regulates TPA‑induced breast cancer cell invasion via PLCγ2/PKCβ/NF‑κB/AP‑1‑dependent matrix metalloproteinase‑9 activation.

Pub. Date : 2021 May

PMID : 33760219






4 Functional Relationships(s)
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1 Bruton"s agammaglobulinemia tyrosine kinase (Btk) regulates TPA-induced breast cancer cell invasion via PLCgamma2/PKCbeta/NF-kappaB/AP-1-dependent matrix metalloproteinase-9 activation. Tetradecanoylphorbol Acetate matrix metallopeptidase 9 Homo sapiens
2 In this study, the anti-metastatic activity of BTK inhibitors was examined in MCF-7 cells focusing on MMP-9 expression in 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated MCF-7 cells. Tetradecanoylphorbol Acetate matrix metallopeptidase 9 Homo sapiens
3 In this study, the anti-metastatic activity of BTK inhibitors was examined in MCF-7 cells focusing on MMP-9 expression in 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated MCF-7 cells. Tetradecanoylphorbol Acetate matrix metallopeptidase 9 Homo sapiens
4 Collectively, results of the present study indicated that BTK suppressed TPA-induced MMP-9 expression and cell invasion/migration by activating the MAPK or IkappaB kinase/NF-kappaB/activator protein-1 pathway. Tetradecanoylphorbol Acetate matrix metallopeptidase 9 Homo sapiens