Pub. Date : 2021 Jul
PMID : 33756436
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Associations between CYP3A4, CYP3A5 and SCN1A polymorphisms and carbamazepine metabolism in epilepsy: A meta-analysis. | Carbamazepine | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | We found that the G allele of CYP3A4 rs2242480 markedly decreased the plasma CBZ concentration in epilepsy. | Carbamazepine | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | CONCLUSION: The CYP3A4 rs2242480, CYP3A5 rs776746 and SCN1A rs3812718 polymorphisms may play important roles in CBZ metabolism and resistance, while SCN1A rs2298771 polymorphism is not associated with CBZ in epilepsy. | Carbamazepine | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 4 | CONCLUSION: The CYP3A4 rs2242480, CYP3A5 rs776746 and SCN1A rs3812718 polymorphisms may play important roles in CBZ metabolism and resistance, while SCN1A rs2298771 polymorphism is not associated with CBZ in epilepsy. | Carbamazepine | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |