Title : A novel role of kallikrein-related peptidase 8 in the pathogenesis of diabetic cardiac fibrosis.

Pub. Date : 2021

PMID : 33754057






1 Functional Relationships(s)
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1 The in vitro and in vivo findings further demonstrated that high glucose may promote plakoglobin-dependent cooperation of p53 with HIF-1alpha and Smad3, subsequently increasing the expression of TGF-beta1 and the pro-EndMT target genes of the TGF-beta1/Smad signaling pathway in a KLK8-dependent manner. Glucose tumor protein p53 Homo sapiens