Title : Decoy Receptor 3 Inhibits Monosodium Urate-Induced NLRP3 Inflammasome Activation via Reduction of Reactive Oxygen Species Production and Lysosomal Rupture.

Pub. Date : 2021

PMID : 33746978






3 Functional Relationships(s)
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1 In bone marrow-derived macrophages, THP-1 and U937 cells, we found that the MSU crystal-induced secretion of IL-1beta and activation of NLRP3 were suppressed by both DcR3.Fc and HBD.Fc. Uric Acid NLR family pyrin domain containing 3 Homo sapiens
2 The suppression of the MSU-induced NLRP3 inflammasome activation is accompanied by the inhibition of lysosomal rupture, mitochondrial production of the reactive oxygen species (ROS), expression of cathepsins, and activity of cathepsin B, without affecting the crystal uptake and the expression of NLRP3 or pro-IL-1beta. Uric Acid NLR family pyrin domain containing 3 Homo sapiens
3 The suppression of the MSU-induced NLRP3 inflammasome activation is accompanied by the inhibition of lysosomal rupture, mitochondrial production of the reactive oxygen species (ROS), expression of cathepsins, and activity of cathepsin B, without affecting the crystal uptake and the expression of NLRP3 or pro-IL-1beta. Uric Acid NLR family pyrin domain containing 3 Homo sapiens