Title : Chalcones and their B-aryl analogues as myeloperoxidase inhibitors: In silico, in vitro and ex vivo investigations.

Pub. Date : 2021 May

PMID : 33744807






2 Functional Relationships(s)
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1 Potent ex vivo MPO inhibitors 5, 8 and 9 were not toxic to human neutrophils at 50 microM, as well as displayed weak 2,2-diphenyl-1-pycrylhydrazyl radical (DPPH ) and hypochlorous acid (HOCl) scavenger abilities. Hypochlorous Acid myeloperoxidase Homo sapiens
2 Potent ex vivo MPO inhibitors 5, 8 and 9 were not toxic to human neutrophils at 50 microM, as well as displayed weak 2,2-diphenyl-1-pycrylhydrazyl radical (DPPH ) and hypochlorous acid (HOCl) scavenger abilities. Hypochlorous Acid myeloperoxidase Homo sapiens