Title : Sildenafil prevents HDACi-induced Epstein-Barr virus reactivation through the PKG pathway in NK/T cell lymphoma; potential implications for HDACi-mediated fatal complications.

Pub. Date : 2021 May

PMID : 33741394






4 Functional Relationships(s)
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1 We found that phosphodiesterase 5 (PDE5) inhibitors, including sildenafil (Viagra; Pfizer), appeared to be nontoxic and effective inhibitors of romidepsin-induced EBV reactivation. Sildenafil Citrate phosphodiesterase 5A Homo sapiens
2 We also investigated the molecular consequences downstream of sildenafil-induced PDE5 inhibition in NKTL cells. Sildenafil Citrate phosphodiesterase 5A Homo sapiens
3 Co-treatment with romidepsin and sildenafil (inhibiting HDAC and PDE5, respectively) showed a synergistic inhibitory effect on NKTL cells, highlighting PDE5 as an attractive target for future therapy in NKTL. Sildenafil Citrate phosphodiesterase 5A Homo sapiens
4 Co-treatment with romidepsin and sildenafil (inhibiting HDAC and PDE5, respectively) showed a synergistic inhibitory effect on NKTL cells, highlighting PDE5 as an attractive target for future therapy in NKTL. Sildenafil Citrate phosphodiesterase 5A Homo sapiens