Pub. Date : 2021 May
PMID : 33741394
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | We found that phosphodiesterase 5 (PDE5) inhibitors, including sildenafil (Viagra; Pfizer), appeared to be nontoxic and effective inhibitors of romidepsin-induced EBV reactivation. | Sildenafil Citrate | phosphodiesterase 5A | Homo sapiens |
2 | We also investigated the molecular consequences downstream of sildenafil-induced PDE5 inhibition in NKTL cells. | Sildenafil Citrate | phosphodiesterase 5A | Homo sapiens |
3 | Co-treatment with romidepsin and sildenafil (inhibiting HDAC and PDE5, respectively) showed a synergistic inhibitory effect on NKTL cells, highlighting PDE5 as an attractive target for future therapy in NKTL. | Sildenafil Citrate | phosphodiesterase 5A | Homo sapiens |
4 | Co-treatment with romidepsin and sildenafil (inhibiting HDAC and PDE5, respectively) showed a synergistic inhibitory effect on NKTL cells, highlighting PDE5 as an attractive target for future therapy in NKTL. | Sildenafil Citrate | phosphodiesterase 5A | Homo sapiens |