Pub. Date : 2021 Jun
PMID : 33741330
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Modulation of autophagy by rapamycin, 3-methyladenine or ATG-5 knockdown regulated the expression of CAFs markers, suggesting a role of autophagy in the tumor promotion mechanism of TGF-beta1-induced CAFs activation. | 3-methyladenine | transforming growth factor beta 1 | Homo sapiens |
2 | We demonstrated that TGF-beta1-activated CAFs promote tumor invasion, pulmonary metastasis and EMT, which act through autophagy and overexpression of FAP-alpha in both models, while autophagy inhibitor 3-methyladenine blocked these effects induced by TGF-beta1-activated CAFs. | 3-methyladenine | transforming growth factor beta 1 | Homo sapiens |
3 | We demonstrated that TGF-beta1-activated CAFs promote tumor invasion, pulmonary metastasis and EMT, which act through autophagy and overexpression of FAP-alpha in both models, while autophagy inhibitor 3-methyladenine blocked these effects induced by TGF-beta1-activated CAFs. | 3-methyladenine | transforming growth factor beta 1 | Homo sapiens |