Title : Treatment of 13-cis retinoic acid and 1,25-dihydroxyvitamin D3 inhibits TNF-alpha-mediated expression of MMP-9 protein and cell invasion through the suppression of JNK pathway and microRNA 221 in human pancreatic adenocarcinoma cancer cells.

Pub. Date : 2021

PMID : 33730072






2 Functional Relationships(s)
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1 Cotreatment of 13-cis RA and 1,25-VD3 also inhibited TNF-alpha mediated expression of matrix metalloproteinase-9 (MMP-9) protein through blocking c-Jun N-terminal kinase (JNK) and nuclear factor kappa B (NF-kappaB) signaling pathways. Radium tumor necrosis factor Homo sapiens
2 These results suggest that 13-cis RA and 1,25-VD3 significantly suppress TNF-alpha mediated cell invasion and therefore potentially act as preventive agents against PDAC. Radium tumor necrosis factor Homo sapiens