Title : Reduction of WDR81 impairs autophagic clearance of aggregated proteins and cell viability in neurodegenerative phenotypes.

Pub. Date : 2021 Mar

PMID : 33730050






3 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 WDR81 facilitates the recruitment of autophagic proteins onto Htt polyQ aggregates and promotes autophagic clearance of Htt polyQ subsequently. polyglutamine huntingtin Homo sapiens
2 WDR81 facilitates the recruitment of autophagic proteins onto Htt polyQ aggregates and promotes autophagic clearance of Htt polyQ subsequently. polyglutamine huntingtin Homo sapiens
3 The BEACH and MFS domains of WDR81 are sufficient for its recruitment onto Htt polyQ aggregates, and its WD40 repeats are essential for WDR81 interaction with covalent bound ATG5-ATG12. polyglutamine huntingtin Homo sapiens