Pub. Date : 2021 May 15
PMID : 33722593
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | COVID-19 and IL-6: Why Vitamin D (probably) helps but tocilizumab might not. | Vitamin D | interleukin 6 | Homo sapiens |
| 2 | Could Vitamin D, which modulates IL-6, be more effective than currently deployed IL-6 antagonists, including tocilizumab, thereby presenting a useful therapeutic option in COVID-19? | Vitamin D | interleukin 6 | Homo sapiens |
| 3 | While tocilizumab non-selectively blocks both anti-inflammatory and pro-inflammatory actions of IL-6, Vitamin D lowers immune cell IL-6 production, potentially reducing pro-inflammatory effects, but does not specifically target IL-6 receptors, avoiding any deleterious effect on the anti-inflammatory actions of IL-6. | Vitamin D | interleukin 6 | Homo sapiens |
| 4 | While tocilizumab non-selectively blocks both anti-inflammatory and pro-inflammatory actions of IL-6, Vitamin D lowers immune cell IL-6 production, potentially reducing pro-inflammatory effects, but does not specifically target IL-6 receptors, avoiding any deleterious effect on the anti-inflammatory actions of IL-6. | Vitamin D | interleukin 6 | Homo sapiens |
| 5 | Vitamin D may have advantages over tocilizumab as an IL-6 immunomodulator, and, given that it is safe if administered under clinical supervision, there is a strong rationale for its use. | Vitamin D | interleukin 6 | Homo sapiens |