Pub. Date : 2021 Apr
PMID : 33715230
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | ATM inhibitor KU-55933 induces apoptosis and inhibits motility by blocking GLUT1-mediated glucose uptake in aggressive cancer cells with sustained activation of Akt. | 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one | solute carrier family 2 (facilitated glucose transporter), member 1 | Mus musculus |
| 2 | In the present study, we found that aggressive breast and prostate cancer cell lines with overactivated Akt activity exhibit enhanced glucose uptake and GLUT1 translocation upon insulin treatment, and KU-55933, a specific inhibitor of ATM, inhibits insulin-mediated glucose uptake by blocking translocation of GLUT1 to the cell surface. | 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one | solute carrier family 2 (facilitated glucose transporter), member 1 | Mus musculus |
| 3 | KU-55933 treatment also inhibits tumor growth and metastasis in vivo in mouse mammary tumors through inhibition of GLUT1 translocation and vimentin expression. | 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one | solute carrier family 2 (facilitated glucose transporter), member 1 | Mus musculus |
| 4 | These results suggest that ATM acts as a promoter of tumorigenesis in cancer cells with overactivated Akt, and KU-55933 induces apoptosis and inhibits motility by blocking GLUT1-mediated glucose uptake and glycolysis in these cancer cells, which may lead to the use of KU-55933 and its analogs as new preventive or therapeutic agents against cancer. | 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one | solute carrier family 2 (facilitated glucose transporter), member 1 | Mus musculus |
| 5 | These results suggest that ATM acts as a promoter of tumorigenesis in cancer cells with overactivated Akt, and KU-55933 induces apoptosis and inhibits motility by blocking GLUT1-mediated glucose uptake and glycolysis in these cancer cells, which may lead to the use of KU-55933 and its analogs as new preventive or therapeutic agents against cancer. | 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one | solute carrier family 2 (facilitated glucose transporter), member 1 | Mus musculus |