Title : Loss of sarcomeric proteins via upregulation of JAK/STAT signaling underlies interferon-γ-induced contractile deficit in engineered human myocardium.

Pub. Date : 2021 May

PMID : 33705988






1 Functional Relationships(s)
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1 Application of clinically used JAK/STAT inhibitors, tofacitinib and baricitinib, fully prevented IFNgamma-induced cardiomyopathy, confirming the critical roles of this signaling pathway in inflammatory cardiac disease. tofacitinib interferon gamma Homo sapiens