Pub. Date : 2021 Mar 9
PMID : 33686070
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We found that perturbing Brca1/p53 in luminal progenitors induces aberrant alveolar differentiation pre-malignancy accompanied by pro-tumourigenic changes in the immune compartment. | Phenobarbital | transformation related protein 53, pseudogene | Mus musculus |
| 2 | Based on our data we propose a model where Brca1/p53 LOF inadvertently promotes a differentiation program hardwired in luminal progenitors, highlighting the deterministic role of the cell-of-origin and offering a potential explanation for the tissue specificity of BRCA1 tumours. | Phenobarbital | transformation related protein 53, pseudogene | Mus musculus |