Pub. Date : 1988 Jan
PMID : 3368009
1 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | On the basis of studies in vitro it is concluded that the observed metabolic interaction between carbamazepine and imipramine is due to the competition of the drugs for the active centre of cytochrome P 450 and to a certain qualitative alteration of the enzyme by imipramine as can be deducted from the decrease of carbamazepine binding to the cytochrome. | Imipramine | cytochrome P450, family 2, subfamily g, polypeptide 1 | Rattus norvegicus |