Pub. Date : 2021
PMID : 33679301
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We found that boldine interacts with Abeta in silico affecting its aggregation and protecting hippocampal neurons from synaptic failure induced by AbetaO. | boldine | amyloid beta (A4) precursor protein | Mus musculus |
| 2 | We conclude that boldine provides neuroprotection in AD models by both direct interactions with Abeta and by preventing oxidative stress and mitochondrial dysfunction. | boldine | amyloid beta (A4) precursor protein | Mus musculus |
| 3 | Additional studies are required to evaluate the effect of boldine on cognitive and behavioral deficits induced by Abeta in vivo. | boldine | amyloid beta (A4) precursor protein | Mus musculus |