Title : ApoE4 (Δ272-299) induces mitochondrial-associated membrane formation and mitochondrial impairment by enhancing GRP75-modulated mitochondrial calcium overload in neuron.

Pub. Date : 2021 Mar 6

PMID : 33676568






1 Functional Relationships(s)
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1 Furthermore, apoE4 (Delta272-299) expression promoted GRP75 expression, mitochondrial dysfunction and calcium transport into the mitochondria in neuron, which were significantly mitigated by treatment with PBA (an inhibitor of ER stress), MKT077 (a specific GRP75 inhibitor) or GRP75 silencing. 4-phenylbutyric acid apolipoprotein E Homo sapiens