Pub. Date : 2021 May 15
PMID : 33676037
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Folylpoly-gamma-glutamate synthetase association to the cytoskeleton: Implications to folate metabolon compartmentalization. | Folic Acid | folylpolyglutamate synthase | Homo sapiens |
| 2 | Following carrier-mediated uptake, folates are polyglutamylated by folylpoly-gamma-glutamate synthetase (FPGS), resulting in their intracellular retention. | Folic Acid | folylpolyglutamate synthase | Homo sapiens |
| 3 | Following carrier-mediated uptake, folates are polyglutamylated by folylpoly-gamma-glutamate synthetase (FPGS), resulting in their intracellular retention. | Folic Acid | folylpolyglutamate synthase | Homo sapiens |
| 4 | SIGNIFICANCE: FPGS, an essential enzyme catalyzing intracellular folate polyglutamylation and efficient retention, was described as a soluble cytosolic enzyme in the past 40 years. | Folic Acid | folylpolyglutamate synthase | Homo sapiens |
| 5 | However, based on the lability of folates and the compartmentalization of folate metabolism and nucleotide biosynthesis, we herein hypothesized that cytoplasmic FPGS is associated with the cytoskeleton, to couple folate transport and polyglutamylation as well as channel folate polyglutamates to biosynthetic metabolon compartments. | Folic Acid | folylpolyglutamate synthase | Homo sapiens |
| 6 | However, based on the lability of folates and the compartmentalization of folate metabolism and nucleotide biosynthesis, we herein hypothesized that cytoplasmic FPGS is associated with the cytoskeleton, to couple folate transport and polyglutamylation as well as channel folate polyglutamates to biosynthetic metabolon compartments. | Folic Acid | folylpolyglutamate synthase | Homo sapiens |
| 7 | However, based on the lability of folates and the compartmentalization of folate metabolism and nucleotide biosynthesis, we herein hypothesized that cytoplasmic FPGS is associated with the cytoskeleton, to couple folate transport and polyglutamylation as well as channel folate polyglutamates to biosynthetic metabolon compartments. | Folic Acid | folylpolyglutamate synthase | Homo sapiens |
| 8 | However, based on the lability of folates and the compartmentalization of folate metabolism and nucleotide biosynthesis, we herein hypothesized that cytoplasmic FPGS is associated with the cytoskeleton, to couple folate transport and polyglutamylation as well as channel folate polyglutamates to biosynthetic metabolon compartments. | Folic Acid | folylpolyglutamate synthase | Homo sapiens |
| 9 | This novel cytoskeletal localization of cytoplasmic FPGS supports the dynamic channeling of polyglutamylated folates to metabolon compartments to avoid oxidation and intracellular dilution of folates, while enhancing folate-dependent de novo biosynthesis of nucleotides and DNA/protein methylation. | Folic Acid | folylpolyglutamate synthase | Homo sapiens |
| 10 | This novel cytoskeletal localization of cytoplasmic FPGS supports the dynamic channeling of polyglutamylated folates to metabolon compartments to avoid oxidation and intracellular dilution of folates, while enhancing folate-dependent de novo biosynthesis of nucleotides and DNA/protein methylation. | Folic Acid | folylpolyglutamate synthase | Homo sapiens |