Title : IGF1R signaling regulates astrocyte-mediated neurovascular coupling in mice: implications for brain aging.

Pub. Date : 2021 Apr

PMID : 33674953






1 Functional Relationships(s)
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1 We found that mice with disrupted astrocytic IGF1R signaling exhibit impaired NVC responses, decreased stimulated release of the vasodilator gliotransmitter epoxy-eicosatrienoic acids (EETs), and upregulation of soluble epoxy hydrolase (sEH), which metabolizes and inactivates EETs. eets insulin-like growth factor I receptor Mus musculus