Title : DNAJB chaperones suppress destabilised protein aggregation via a region distinct from that used to inhibit amyloidogenesis.

Pub. Date : 2021 Apr 1

PMID : 33674449






1 Functional Relationships(s)
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1 Conversely, deletion of the C-terminal TTK-LKS motif in DNAJB6 and DNAJB8, a region not required to suppress polyQ aggregation, abolished its ability to inhibit inclusion formation by FlucDM Thus, our data suggest that DNAJB6 and DNAJB8 possess two distinct regions for binding substrates, one that is responsible for binding beta-hairpins that form during amyloid formation and another that interacts with exposed hydrophobic patches in aggregation-prone clients. polyglutamine DnaJ heat shock protein family (Hsp40) member B6 Homo sapiens