Pub. Date : 2021 Feb 17
PMID : 33671452
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Regorafenib-Attenuated, Bleomycin-Induced Pulmonary Fibrosis by Inhibiting the TGF-beta1 Signaling Pathway. | regorafenib | transforming growth factor beta 1 | Homo sapiens |
| 2 | Further in vitro mechanism studies showed that regorafenib inhibits the activation and migration of myofibroblasts and extracellular matrix production, mainly through suppressing the transforming growth factor (TGF)-beta1/Smad and non-Smad signaling pathways. | regorafenib | transforming growth factor beta 1 | Homo sapiens |
| 3 | In vitro studies have also indicated that regorafenib could augment autophagy in myofibroblasts by suppressing TGF-beta1/mTOR (mechanistic target of rapamycin) signaling, and could promote apoptosis in myofibroblasts. | regorafenib | transforming growth factor beta 1 | Homo sapiens |
| 4 | In conclusion, regorafenib attenuates bleomycin-induced pulmonary fibrosis by suppressing the TGF-beta1 signaling pathway. | regorafenib | transforming growth factor beta 1 | Homo sapiens |