Pub. Date : 2021 Feb 17
PMID : 33671323
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Pharmacokinetics of the CYP3A4 and CYP2B6 Inducer Carbamazepine and Its Drug-Drug Interaction Potential: A Physiologically Based Pharmacokinetic Modeling Approach. | Carbamazepine | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | The anticonvulsant carbamazepine is frequently used in the long-term therapy of epilepsy and is a known substrate and inducer of cytochrome P450 (CYP) 3A4 and CYP2B6. | Carbamazepine | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | The carbamazepine model applies metabolism by CYP3A4 and CYP2C8 to produce carbamazepine-10,11-epoxide, metabolism by CYP2B6 and UDP-glucuronosyltransferase (UGT) 2B7 and glomerular filtration. | Carbamazepine | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 4 | The carbamazepine model applies metabolism by CYP3A4 and CYP2C8 to produce carbamazepine-10,11-epoxide, metabolism by CYP2B6 and UDP-glucuronosyltransferase (UGT) 2B7 and glomerular filtration. | Carbamazepine | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |