Title : Aspirin Eugenol Ester Protects Vascular Endothelium From Oxidative Injury by the Apoptosis Signal Regulating Kinase-1 Pathway.

Pub. Date : 2020

PMID : 33658932






2 Functional Relationships(s)
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1 The results showed that in the HUVECs, 200 muM H2O2 treatment significantly increased the phosphorylation of SAPK/JNK and the level of ASK1 but decreased the phosphorylation of ERK1/2, while in the HUVECs pretreated with AEE, the H2O2-induced changes were significantly ameliorated. Hydrogen Peroxide mitogen activated protein kinase 3 Rattus norvegicus
2 Moreover, inhibition of ASK1 and ERK1/2 showed that ASK1 plays a vital role in the protective effect of AEE on H2O2-induced apoptosis. Hydrogen Peroxide mitogen activated protein kinase 3 Rattus norvegicus