Title : Shorter androgen receptor polyQ alleles protect against life-threatening COVID-19 disease in European males.

Pub. Date : 2021 Mar

PMID : 33647767






4 Functional Relationships(s)
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Protein Name
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1 Testosterone was higher in subjects with AR long-polyQ, possibly indicating receptor resistance (p = 0.042 Mann-Whitney U test). Testosterone androgen receptor Homo sapiens
2 Failure of the endocrine feedback to overcome AR signaling defects by increasing testosterone levels during the infection leads to the polyQ tract becoming dominant to serum testosterone levels for the clinical outcome. Testosterone androgen receptor Homo sapiens
3 Failure of the endocrine feedback to overcome AR signaling defects by increasing testosterone levels during the infection leads to the polyQ tract becoming dominant to serum testosterone levels for the clinical outcome. Testosterone androgen receptor Homo sapiens
4 These results may contribute to designing reliable clinical and public health measures and provide a rationale to test testosterone as adjuvant therapy in men with COVID-19 expressing long AR polyQ repeats. Testosterone androgen receptor Homo sapiens